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. Author manuscript; available in PMC: 2022 Jan 25.
Published in final edited form as: J Med Chem. 2017 Jan 5;60(2):641–657. doi: 10.1021/acs.jmedchem.6b01474

Figure 4.

Figure 4.

Direct inhibition of serine proteases by NSGM 2. The inhibition of plasmin (●), thrombin (♦), trypsin (■), factor XIa (□), chymotrypsin (○), and factor Xa (△) by inhibitor 2 was studied using chromogenic substrate hydrolysis assay at pH 7.4 and 37 °C, as described in Experimental Part. Solid lines represent the sigmoidal dose–response fits (eq 1) to the data to obtain the values of IC50, ΔY, and HS.