Table 1.

In Vitro Inhibition of Human Plasmin by NSGMs^a

Inhibitor	R1/R1`	R2/R2`	X	IC50 (μM)	HS	Δ Y (%)
1	OSO3Na	OSO3Na		76 ± 12b	1.0 ± 0.2	72 ± 9
2	OSO3Na	OSO3Na		6.3 ± 0.4	0.7 ± 0.1	93 ± 4
3	OSO3Na	OSO3Na		37 ± 7	0.8 ± 0.2	80 ± 11
4	OSO3Na	OSO3Na		6.5 ± 0.7	0.7 ± 0.1	104 ± 7
5	OSO3Na	OSO3Na		73 ± 11	0.6 ± 0.1	107 ± 7
6	OSO3Na	OSO3Na		231 ± 27	0.8 ± 0.2	90 ± 5
7	H	H		71 ± 2	2.4 ± 0.3	79 ± 3
8	H	H		>1000	ND c	ND
9	H	H		282 ± 17	1.8 ± 0.3	90 ± 8
10	H	H		121 ± 18	0.9 ± 0.2	90 ± 11
11	H	H		34 ± 1	2.4 ± 0.3	89 ± 2
12	H	H		47 ± 2	1.1 ± 0.1	79 ± 3
13	H	H		20 ± 1	2.0 ± 0.1	94 ± 2
14	H	H		34 ± 2	2.3 ± 0.5	86 ± 4
15	H	H		42 ± 3	1.2 ± 0.2	63 ± 4
16	H/OSO3Na	H/OSO3Na		14 ± 1	0.9 ± 0.1	109 ± 6

^aThe IC₅₀, HS, and ΔY values were obtained following nonlinear regression analysis of direct inhibition of human plasmin in appropriate Tris-HCl buffers of pH 7.4 at 37 °C. Inhibition was monitored spectrophotometrically. See Experimental Part for details.

^bErrors represent ±1 SE.

^cNot determined.