Table 1.
Participant characteristics for the entire aneurysmal subarachnoid hemorrhage cohort and discovery and replication sample subsets
| Variable | aSAH cohort (n = 648) | Discovery sample (n = 260) | Replication sample (n = 100) | |||
|---|---|---|---|---|---|---|
| Age, mean years (SD) | 53.2 (11.5) | 53.1 (11.0) | 54.2 (12.0) | |||
| Sex, female, n (%) | 469 (72.4) | 179 (68.8) | 76 (76.0) | |||
| Self-identified race, white, n (%) | 563 (86.9) | 225 (86.5) | 91 (91.0) | |||
| Treatment, coil embolization, n (%) | 402 (62.0) | 159 (61.2) | 66 (66.0) | |||
| Fisher grade, n (%) | ||||||
| 2 | 266 (41.0) | 78 (30.0) | 41 (41.0) | |||
| 3 | 279 (43.1) | 126 (48.5) | 43 (43.0) | |||
| 4 | 103 (15.9) | 56 (21.5) | 16 (16.0) | |||
| Outcome | N | Unfavorable, n (%) | N | Unfavorable, n (%) | N | Unfavorable, n (%) |
| CV | 396 | 206 (52.0) | 168 | 91 (54.2) | NAa | |
| DCI | 631 | 253 (40.1) | 258 | 127 (49.2) | ||
| GOS-3 | 555 | 149 (26.8) | 214 | 71 (33.2) | 99 | 38 (38.4) |
| GOS-12 | 530 | 121 (22.8) | 204 | 53 (26.0) | 93 | 29 (31.2) |
| Death-3 | 594 | 88 (14.8) | 232 | 39 (16.8) | 99 | 24 (24.2) |
| Death-12 | 530 | 96 (18.1) | 204 | 44 (21.6) | 93 | 26 (28.0) |
aSAH, aneurysmal subarachnoid hemorrhage; SD, standard deviation; CV, cerebral vasospasm (unfavorable = CV present); DCI, delayed cerebral ischemia (unfavorable = DCI present); GOS-3, Glasgow Outcome Scale at 3 months (unfavorable = 1–3); GOS-12, Glasgow Outcome Scale at 12 months (unfavorable = 1–3); Death-3, death at 3 months (unfavorable = yes); Death-12, death at 12 months (unfavorable = yes);
a
CV and DCI were not examined in the replication sample given null association in discovery analyses