Table 1.
ID | Study arm | Age (years) | Ethnicity | Marital status | Parity | Carrier status | Personal history of BC | RRM | Number of relatives with OC | Number of relatives with BC | Ascertainment | Postcode |
ID-01 | No surgery | 40 | Caucasian | Single | 0 | BRCA1 | No | Yes | 0 | 1 SDR | High-risk FCC | London |
ID-02 | RRSO | 41 | Caucasian | Married | 0 | BRCA2 | No | Yes | 0 | 1 FDR, 1 SDR | High-risk FCC | Essex |
ID-03 | RRESDO | 37 | Caucasian | Married | 3 | BRCA2 | No | No | 1 SDR | 1 FDR, 1 SDR | High-risk FCC | Essex |
ID-04 | RRSO | 46 | Caucasian | Married | 0 | BRCA1 | No | No | 0 | 0 | High-risk FCC | London |
ID-05 | RRESDO | 43 | Caucasian | Single | 2 | BRCA1 | No | No | 1 SDR | 3 SDR | High-risk FCC | London |
ID-06 | RRESDO | 38 | Caucasian | Married | 2 | BRCA1 | No | Yes | 0 | 3 SDR | High-risk FCC | Sussex |
ID-07 | No-surgery | 36 | Asian | Single | 1 | BRCA1 | No | No | 1 SDR | 3 SDR | High-risk FCC | London |
ID-08 | RRESDO | 46 | Caucasian | Married | 3 | BRCA2 | No | Yes | 0 | 1 FDR, 1 SDR | High-risk FCC | Cambridge |
ID-09 | RRESDO | 39 | Caucasian | Married | 2 | BRCA1 | No | Yes | 1 FDR, 1 SDR | 1 FDR | High-risk FCC | London |
ID-10 | No-surgery | 39 | Caucasian | Married | 0 | BRCA1 | No | No | 1 SDR | 1 FDR | High-risk FCC | London |
ID-11 | RRESDO | 35 | Caucasian | Married | 2 | BRCA2 | No | No | 1 FDR | 0 | High-risk FCC | Hertfordshire |
ID-12 | No-surgery | 36 | Caucasian | Married | 1 | BRCA1 | No | No | 2 SDR | 1 SDR | High-risk FCC | London |
ID-13 | RRSO | 45 | Caucasian | Married | 1 | BRCA2 | No | Yes | 0 | 0 | General gynaecology clinic | Durham |
ID-14 | No-surgery | 38 | Caucasian | Married | 1 | BRCA1 | Yes* | No† | 0 | 0 | High-risk FCC | London |
ID-15 | RRESDO | 38 | Caucasian | Married | 2 | BRCA2 | No | No | 0 | 0 | High-risk FCC | Hertfordshire |
ID-16 | RRESDO | 44 | Caucasian | Married | 2 | BRCA2 | No | No | 2 SDR | 1 SDR | High-risk FCC | Hampshire |
ID-17 | RRESDO | 39 | Caucasian | Married | 2 | BRCA1 | Yes‡ | No† | 0 | 0 | GO clinic | Newport |
ID-18 | RRESDO | 44 | Caucasian | Single | 2 | BRCA2 | No | Yes | 0 | 1 FDR, 2 SDR | High-risk FCC | London |
ID-19 | No surgery | 34 | Caucasian | Married | 2 | BRCA1 | No | No | 0 | 1 SDR | Genetics clinic | Surrey |
ID-20 | RRSO | 46 | Asian | Married | 2 | BRCA1 | No | No | 1 FDR, 2 SDR | 2 SDR | GO clinic | Aberdeen |
ID-21 | RRESDO | 44 | Caucasian | Married | 2 | BRCA2 | Yes* | Yes§ | 1 FDR | 1 FDR, 1 SDR | GO clinic | Devon |
ID-22 | RRSO | 39 | Caucasian | Married | 2 | BRCA2 | No | No | 0 | 1 FDR | GO clinic | Liverpool |
ID-23 | RRSO | 40 | Caucasian | Single | 2 | BRCA1 | No | No | 1 FDR, 1SDR | 0 | High-risk FCC | Surrey |
ID-24 | RRSO | 40 | Caucasian | Married | 1 | BRCA1 | Yes‡ | Yes*§ | 0 | 2 FDR | General gynaecology clinic | Cleveland |
*Oestrogen receptor positive breast cancer.
†Bilateral therapeutic mastectomies.
‡Triple negative breast cancer.
§Unilateral therapeutic mastectomy followed by contralateral risk reducing mastectomy.
BC, breast cancer; FCC, familial cancer clinic; FDR, first degree relative; GO, gynaecological oncology; OC, ovarian cancer; RRESDO, risk-reducing early salpingectomy with delayed oophorectomy; RRM, risk-reducing mastectomy; RRSO, risk-reducing salpingo-oophorectomy; SDR, second degree relative.