Table 3.
Rates of pathogenic variants found in patients with DCIS
| DCIS | Total cases | Total PVs | % | BRCA1 | % | BRCA2 | % | TP53 | % |
BRCA1/BRCA2/
TP53 combined (%) |
PALB2 | % |
| Total | 26 | 11 | 42.3 | 2 | 7.7 | 2 | 7.7 | 6 | 23.10 | 38.5 | 1 | 3.8 |
| ≤25 years | 8 | 3 | 37.5 | 0 | 0.0 | 1 | 12.5 | 2 | 25.00 | 37.5 | 0 | 0.0 |
| 26–30 years | 18 | 8 | 44.4 | 2 | 11.1 | 1 | 5.6 | 4 | 22.20 | 38.9 | 1 | 5.6 |
| Grade/type | ||||||||||||
| Unknown | 3 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0.0 | 0 | 0.0 |
| 2 | 8 | 2 | 25.0 | 0 | 0.0 | 1 | 12.5 | 0 | 0% | 12.5 | 1 | 12.5 |
| 3 | 14 | 8 | 57.1 | 2 | 14.3 | 1 | 7.1 | 5 | 36 | 57.1 | 0 | 0.0 |
| Pagets | 1 | 1 | 100.0 | 0 | 0.0 | 0 | 0.0 | 1 | 100 | 100.0 | 0 | 0.0 |
| Comedo | 8 | 4 | 50.0 | 0 | 0.0 | 0 | 0.0 | 4 | 50 | 50.0 | 0 | 0.0 |
PV, pathogenic variant.