TABLE 1.
Bacterial counts from rat small intestinea
| Agent | Median CFU/mL (IQR) |
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|---|---|---|---|---|---|---|
| Aerobic |
Anaerobic |
Strictly anaerobic |
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| Proximal small intestine | Ileum | Proximal small intestine | Ileum | Proximal small intestine | Ileum | |
| D | 1.7E+7 (3.1E+6 to 1.5E+6) | 3.6E+7 (2.5E+7 to 4.2E+6) | 4.2E+7 (1.6E+7 to 2.3E+6) | 5.9E+7 (4.1E+7 to 1.4E+7) | 1.1E+7 (7.0E+6 to 8.0E+5) | 2.2E+7 (1.0E+7 to 5.0E+6) |
| P | 2.4E+7 (1.5E+7 to 2.2E+6) | 5.6E+7 (2.5E+7 to 1.4E+7) | 6.2E+7 (3.8E+7 to 4.6E+6) | 3.4E+8 (6.8E+7 to 2.1E+7)# | 2.6E+7 (2.1E+7 to 2.4E+6) | 1.2E+8 (4.0E+7 to 2.7E+6)## |
| R | 1.0E+7 (4.6E+6 to 1.3E+6) | 1.8E+8 (7.5E+7 to 3.6E+7)* | 2.7E+7 (1.0E+7 to 3.9E+6) | 2.8E+8 (1.2E+8 to 4.4E+7)* | 1.3E+7 (2.6E+6 to 7.0E+5) | 1.7E+8 (1.9E+7 to −1.8E+8) |
| VH | 3.5E+7 (9.5E+6 to 2.6E+6) | 2.4E+7 (2.1E+7 to 7.0E+6) | 6.9E+7 (2.8E+7 to 3.8E+6) | 7.0E+7 (4.8E+7 to 3.4E+7) | 3.5E+7 (1.7E+7 to 1.2E+6) | 2.5E+7 (1.1E+7 to −3.0E+7) |
a
The proximal small intestinal and ileal CFU/mL were counted after 48 h aerobic or anaerobic incubation of jejunal and ileal content. Strict anaerobic counts were estimated by subtracting the anaerobic counts with the aerobic counts. IQR, interquartile range; D, dopamine; P, pramipexole; R, ropinirole; VH, vehicle (10% sucrose). Extreme outliers were removed using the ROUT method (Q = 0.1%). Significance, compared to VH, was tested with one-way ANOVA followed by Fisher’s LSD test with FDR correction (q < 0.1). #, P = 0.054, q = 0.080; ##, P = 0.046, q = 0.138.