Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 24;9(1):e000615. doi: 10.1136/lupus-2021-000615

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

DGE in class V lupus nephritis compared with idiopathic MN. (A) Volcano plot depicting DGE of class V LN (n=21 biopsies) vs MN (n=9 biopsies). Benjamini-Hochberg adjusted p=0.05 and log2 FC cut-off=0.5. (B) STRING interaction network for all 26 significant differentially expressed genes between class V LN and MN (highest confidence score=0.9). Red nodes—type I IFN; orange nodes—regulation of type III IFN. (C) Heatmap of type I IFN-associated genes across the entire cohort (LN n=55 biopsies, MN n=9 biopsies, TBM n=14 biopsies). IFN status refers to blood IFN score (see methods). DGE, differential gene expression; FC, fold change; MN, membranous nephropathy; TRI, tubuloreticular inclusions.