Skip to main content
. 2022 Jan 24;9(1):e000615. doi: 10.1136/lupus-2021-000615

Figure 4.

Figure 4

Differential gene expression between class IV and class V LN. Volcano plots depicting differential gene expression (DGE) of class IV (n=23 biopsies) vs class V (n=21 biopsies). Benjamini-Hochberg adjusted p=0.05 and log2 FC cut-off=0.5. (B) STRING interaction network for 167 significant differentially expressed genes with expression higher in class IV vs class V (highest confidence score=0.9). Red nodes—type I IFN; blue nodes—complement cascade; pink nodes—MHC II; yellow nodes—JAK-STAT signalling; purple nodes—integrin binding; light green nodes—NF-κB+TIR domain; dark green nodes—NF-κB and apoptosis modulation. FC, fold change; LN, lupus nephritis; NS, non-significant.