Table 2.

Odds ratios (95% confidence intervals) for the relation of mental and physical health with later COVID-19 vaccine hesitancy in Understanding Society (N = 7361).

	Number hesitant/Total at risk	Age, sex, & ethnicity	All covariates
Psychiatric morbidity
Anxiety	50/324	1.00 (0.72, 1.36)	1.11 (0.79, 1.52)
Depression	54/368	0.99 (0.72, 1.33)	1.12 (0.81, 1.53)
Other mental health condition(s)	20/111	1.08 (0.64, 1.75)	1.21 (0.71, 1.97)
Any mental health condition	71/491	0.99 (0.75, 1.29)	1.14 (0.86, 1.49)
Psychological distress
Asymptomatic (score 0)	443/3339	1.0 (ref)	1.0 (ref)
Subclinically symptomatic (1–3)	247/2256	0.77 (0.64, 0.91)	0.81 (0.63, 0.98)
Symptomatic (4–6)	90/750	0.77 (0.59, 0.98)	0.82 (0.56, 1.07)
Highly symptomatic (7–12)	173/1016	1.05 (0.85, 1.28)	1.12 (0.92, 1.33)
P for quadratic association		<0.0001	0.003
P for linear trend		0.251	0.075
Per SD (3.5 points) decrease	953/7361	0.93 (0.81, 1.06)	0.88 (0.75, 1.02)
Physical morbidity
Cardiometabolic disease	147/1905	0.82 (0.67, 0.99)	0.78 (0.64, 0.95)
Respiratory disease	107/1034	0.71 (0.57, 0.88)	0.74 (0.59, 0.93)
Any cancer	29/389	0.87 (0.58, 1.28)	0.95 (0.62, 1.39)
Any physical health condition	225/2389	0.72 (0.61, 0.85)	0.72 (0.60, 0.85)
Shielding in household	88/889	0.81 (0.63, 1.03)	0.76 (0.59, 0.96)

All covariates are: age, sex, ethnicity, education, shielding status, and cognitive function. Effect estimates for physical morbidity and psychiatric morbidity were mutually-adjusted.