Table 3.
Mechanical properties (hardness, cohesiveness, adhesiveness), mucoadhesion force, and work of adhesion of some selected L-carnosine in situ gels.
| In situ gels | Temperature (4 °C) |
Temperature (35 °C) |
Mucoadhesion |
|||||
|---|---|---|---|---|---|---|---|---|
| Hardness (mN) | Cohesiveness (mN·mm) | Adhesiveness (mN·mm) | Hardness (mN) | Cohesiveness (mN·mm) | Adhesiveness (mN·mm) | Adhesion force (mN) | Work of adhesion (mN·mm) | |
| F-P3 | 17.3 ± 0.2 | 152.5 ± 3.2 | 86.1 ± 2.0 | 190.3 ± 10.1 | 776 ± 2.1 | 911 ± 2.9 | 110 ± 5.5 | 210 ± 15.5 |
| F-P3/CS0.5 | 22.6 ± 1.6 | 115.4 ± 3.2 | 33.1 ± 3.9 | 101.3 ± 2.7 | 411 ± 3.5 | 836.2 ± 5.9 | 136 ± 8.5 | 285 ± 7.5 |
| F-P3/CS1 | 24.1 ± 1.3 | 270.4 ± 2.9 | 39.5 ± 1.9 | 183.4 ± 1.6 | 654 ± 6.1 | 1014 ± 8.8 | 170 ± 12.5 | 345 ± 4.5 |
| F-P3/MC0.5 | 17.1 ± 2.1 | 116.4 ± 0.9 | 30.1 ± 6.3 | 280 ± 3.4 | 1037 ± 7.9 | 1210 ± 6.0 | 107 ± 10.5 | 170 ± 6.5 |
| F-P3/MC1 | 23.1 ± 1.1 | 121 ± 6.3 | 41.1 ± 2.8 | 326.1 ± 6.4 | 1193 ± 11.2 | 1498 ± 10.4 | 87.5 ± 4.8 | 115 ± 2.5 |
Data are expressed as mean values ± SD (n = 3).