Figure 3.

Schematic of how the chromatin may loop to activate genes within the transcriptionally complex Hoxb gene cluster (A) Different loop confirmations envisioned for activation of specific genes within the Hoxb cluster, which contains several enhancer elements (such as DE, B4U and ENE) as well as coding and non-coding genes. (B) Inference [41,44] for how nascent Hoxb transcripts may promote condensate formation to increase nascent transcription, and subsequently, how an increased number of nascent transcripts may inhibit transcription by promoting condensate dissolution. Brown boxes at cluster edges depict boundary elements, blue and pink colored ovals depict coding genes and non-coding RNAs, respectively, and green ovals are RARE enhancers.