Table 2.
Significant atrophy in brain regions of interest—FTD vs. CO.
| Brain Region of Interest | Mean Volume in FTD (in mm3) | Mean Volume in CO (in mm3) | Level of Significance (p) |
|---|---|---|---|
| MFG-DPFC left | 9525.6 | 11,480.0 | 0.053 |
| MFG-DPFC-right | 9763.6 | 11,947.1 | 0.031 |
| IFGO left | 2755.0 | 3347.1 | 0.023 |
| IFGO right | 2062.2 | 2622.6 | 0.002 |
| MFOG right | 3534.4 | 4028.0 | 0.041 |
| RG left | 3770.2 | 4625.9 | 0.026 |
| RG right | 3747.6 | 4691.5 | 0.006 |
| STG left | 9212.4 | 11,653.5 | 0.004 |
| STG right | 8948.2 | 10,913.4 | 0.004 |
| STG-pole left | 4168.4 | 5227.8 | 0.013 |
| AG left | 5866.8 | 6770.3 | 0.048 |
| SOG left | 2051.2 | 2395.6 | 0.030 |
| Insula left | 5104.8 | 6127.6 | 0.038 |
| Insula right | 5202.0 | 6141.0 | 0.024 |
| Amygdala left | 1071,8 | 1497,9 | 0.000 |
| Amygdala right | 1217.2 | 1630.7 | 0.006 |
| Hippocampus left | 2868.4 | 3442.0 | 0.022 |
| Putamen left | 2886.0 | 3684.6 | 0.001 |
| Putamen right | 3152.0 | 3876.3 | 0.002 |
| GP left | 1124.2 | 1340.4 | 0.025 |
| Thalamus left | 4468.4 | 5237.5 | 0.034 |
| Thalamus right | 4668.8 | 5348.7 | 0.041 |
| NucAccumbens right | 604.6 | 730.8 | 0.049 |
| Snigra left | 261.0 | 318.8 | 0.026 |
| Snigra right | 210.8 | 256.3 | 0.048 |
| CP left | 1536.2 | 1858.2 | 0.026 |
| CP right | 1623.4 | 1916.5 | 0.050 |
| ICP left | 631.4 | 761.0 | 0.036 |
| SCR left | 13,355.8 | 15,739.9 | 0.044 |
| PCR left | 5040.6 | 6124.4 | 0.013 |
| PCR right | 4243.2 | 5156.5 | 0.036 |
| EC left | 2514.0 | 2862.1 | 0.034 |
| EC right | 2433.0 | 2821.2 | 0.035 |
| IFO left | 1534.8 | 1765.8 | 0.024 |
| IFO right | 1561.2 | 1787.8 | 0.024 |
| SS right | 3210.8 | 4012.9 | 0.009 |
| CI right | 264.2 | 374.7 | 0.003 |
| Basal Forebrain left | 462.6 | 536.5 | 0.044 |
| IFWMO left | 1818.8 | 2283.6 | 0.008 |
| IFWMO right | 1543.2 | 1881.6 | 0.010 |
| Caudate-tail left | 273.4 | 338.1 | 0.030 |
| Caudate-tail right | 253.8 | 347.0 | 0.022 |
| Fimbria right | 16.4 | 36.5 | 0.011 |
Note: FTD indicates frontotemporal dementia; CO, control subjects.