Figure 4.

Thermal stability of cetuximab-derived scFv-monoFc proteins (A) and mAbs (B), as determined by dynamic light scattering. Data are representative of two independent experiments. Unfolding temperatures (the point at which the radius surpassed 10 nm) are shown in Table 2 and Table 3. N85E is aglycosylated cetuximab, whereas H1 through H11 are humanized variants.