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. 2021 Jun 25;24(1):90–96. doi: 10.4103/aja.aja_51_21

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Copyright: ©The Author(s)(2021)

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Restoration of PPARγ2 activity in PC3 and LNCaP cells inhibited cellular proliferation and migration in vitro. (a) Restoration of specific PPARγ2 isoform activity using WT full-length human PPARγ2 cDNA in PC3 and LNCaP cells by stable transfection was used to create a series of isogenic cell lines for genetic and functional comparisons. PPARγ2 protein expression was validated by western blot analysis. The proliferation of (b) PC3- and (c) LNCaP-PPARγ2 cDNA-restored cells was significantly inhibited compared with that of control cells. ^*P < 0.05, n = 6 for each group. The migration of (d) PC3- and (e) LNCaP-PPARγ2-restored cells was significantly inhibited compared with that of control cells. ^*P < 0.05, n = 6 for each group. WT: wild type; EV: empty vector; PPARγ2: peroxisome proliferators-activated receptors γ 2.