Figure 6.

A schematic showing a proposed translational model for functional dissection of the PPARγ2 isoform in human prostate cancer initiation and progression in vitro and in vivo. Specific PPARγ2 isoform gain of function in PC3 advanced human prostate cancer cells resulted in increased cancer cell differentiation and severe necroptosis with stromal leukocyte infiltration. These findings deepen our understanding of the effects of the effects of the specific PPARγ2 isoform on human prostate epithelial cellular homeostasis and provide a novel strategy for preventing prostate carcinogenesis and blocking cancer progression. PPARγ2: peroxisome proliferators-activated receptors γ 2.