Table 2.
In silico missense prediction of biallelic mutations in spermatogenesis and centriole-associated 1 like
| Algorithm | c.910C>T:p.Arg304Cys (predicted value) | c.994G>T:p.Glu332X (predicted value) |
|---|---|---|
| SIFT | Damaging (0.001) | NA |
| LRT | Deleterious (0) | Neutral (0.004) |
| MutationTaster | Disease-causing (1) | Disease-causing (1) |
| PROVEAN | Damaging (−4.63) | NA |
| CADD | Damaging (25.2) | Damaging (41) |
| DANN | Damaging (0.999) | Damaging (0.996) |
| GenoCanyon | Damaging (1) | Damaging (1) |
| fitCons | Damaging (0.706) | Damaging (0.706) |
| ClinPred | Pathogenic (0.88554954) | NA |
NA: not available; SIFT: sorting intolerant from tolerant; LRT: likelihood ratio test; PROVEAN: protein variation effect analyzer; CADD: combined annotation dependent depletion; DANN: deleterious annotation of genetic variants using neural networks