Fig. 1.
Drug treatment more than doubled the age of cataplexy onset. Seven narcoleptic dogs (two males, five females) were treated with a combination of methylprednisolone, azathioprine and methotrexate. Seven narcoleptic dogs (three males, four females) were not treated and served as controls. Drug treatment started at 3 weeks of age for the first litter and at 3 days of age for the subsequent four litters. The difference between the groups was significant (F = 17.9; df = 1,12; P < 0.001; t test with Bonferroni correction). Means ± SEM are shown.