Fig. 3.

Short-term drug administration did not reduce cataplexy, demonstrating that the reduction of symptoms during treatment was not mediated by a direct effect of the treatment drugs on symptoms. (A) FECT times were not reduced during a 3-day treatment of an otherwise untreated narcoleptic dog, age 3 months, from the first litter. Drugs were administered at the same dosages as were given to treated dogs. (B) FECT times were not reduced when the same dog was treated for a 2-week period at 6 months of age. (C) Time spent in cataplexy during mFECTs was not reduced for three transiently treated narcoleptic dogs from subsequent litters. These otherwise untreated dogs underwent a 5-day course of immunosuppression at 4.5 months of age, receiving drugs at the same dosages as were given to treated littermates. Means ± SEM are shown.