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Induction of antigen-specific antibody responses in serum. PsaA-PspA23-SA- (A), PspA4-SA- (B), and CPS4-specific (C) IgG titers. Post 1, post 2, and post 3 represent the specific antibody titers after the first, second, and third immunizations, respectively. The dashed line indicates the anti-CPS4 IgG titer in serum from mice receiving three immunizations with PCV13. *, P < 0.05; **, P < 0.01; ***, P < 0.001. ns, not significant.
