FIG 5.

Invasion inhibitory potential of affinity purified CyRPA specific naturally acquired human antibodies. The purified CyRPA specific human antibodies were tested in the standard in vitro growth inhibition assay (GIA) in a one-cycle assay against 3D7. The graph shows GIA with CyRPA-specific human antibody (black line) and naive human antibody (dashed line), calculated against a nonantibody control. A dose-dependent inhibitory response was observed, and a maximum inhibition of ∼44% was achieved at 250 μg/mL IgG concentration. Data represent the average of two independent experiments conducted in duplicate. Error bars represent the standard error between the two independent GIA experiments.