Table 1.
The 34 Natural Product BGCs Identified After Manual Curation of an AntiSMASH v 5.0 (Blin et al., 2019) Analysis of the NRRL B-65442 Chromosome Sequence. The Seven Previously Identified NRRL B-65442 BGCs With Their Characterised Products Are Indicated by Asterisks. While Not Derived From NRRL B-65442, the Products of BGC 6 ((+)-isodauc-8-en-11-ol; (Rabe et al., 2015)) and BGC 29 (Foroxymithine; (Kodani et al., 2015)) Were Determined from Experiments With the ATCC 10712 Strain.
BGC | Type | From nt | To nt | Known or most similar BGC |
---|---|---|---|---|
1 | Ectoine | 237,110 | 247,526 | Ectoine |
2 | Terpene | 273,798 | 294,749 | Geosmin |
3 | Type 1 PKS—Type 3 PKS | 519,875 | 549,437 | Venemycin* |
4 | NRPS-like | 554,017 | 582,919 | Watasemycin* |
5 | Ripp (lanthipeptide) | 613,767 | 629,532 | |
6 | Terpene | 633,034 | 634,179 | (+)-isodauc-8-en-11-ol |
7 | Ripp (lanthipeptide) | 716,117 | 728,969 | Venezuelin* |
8 | Indole | 871,837 | 882,258 | Arcyriaflavin* |
9 | NRPS-like | 1,038,563 | 1,060,601 | Chloramphenicol* |
10 | tRNA-dependent cyclodipeptide synthase | 2,070,178 | 2,090,903 | |
11 | Siderophore | 2,798,699 | 2,809,633 | Desferrioxamine B |
12 | Ripp (lasso peptide) | 3,410,820 | 3,433,179 | Albusnodin |
13 | NRPS-like | 4,408,114 | 4,450,353 | |
14 | Other | 4,520,077 | 4,530,222 | Gaburedins* |
15 | Melanin | 5,001,915 | 5,010,131 | |
16 | Other | 5,475,407 | 5,516,513 | |
17 | Ripp (thiopeptide) | 5,525,842 | 5,558,923 | |
18 | Type 3 PKS | 5,784,219 | 5,822,500 | Flaviolin |
19 | Siderophore | 5,872,827 | 5,885,289 | |
20 | Siderophore | 5,938,343 | 5,952,704 | |
21 | Type 2 PKS | 6,473,487 | 6,545,282 | Jadomycin* |
22 | NRPS-like | 6,673,724 | 6,714,283 | |
23 | NRPS-PKS | 6,719,994 | 6,853,949 | |
24 | Terpene | 7,020,609 | 7,045,713 | Hopene |
25 | Ripp (Lanthipeptide) | 7,061,572 | 7,084,199 | SapB |
26 | Bacteriocin | 7,127,295 | 7,138,149 | Linocin M18 |
27 | Type 2 PKS | 7,403,744 | 7,476,256 | Spore pigment |
28 | Melanin | 7,482,101 | 7,492,490 | Melanin |
29 | NRPS | 7,704,299 | 7,757,163 | Salinichelins |
30 | Terpene | 7,785,725 | 7,805,848 | 2-methylisoborneol |
31 | Type 3 PKS | 7,943,145 | 7,984,236 | Alkylresorcinol |
32 | Insecticidal protein | 8,173,009 | 8,194,753 | |
33 | Terpene | 8,196,208 | 8,197,119 | |
34 | NRPS | 8,208,224 | 8,212,381 |