TABLE 1.

E. huxleyi CCMP3266 gene expression in cocultures exhibits down- and upregulation of key biological processes during the transition from exponential growth to algal demise (Fig. 1)^a

Process no.	GO iD	Term	Annotated	Significant	Expected	P
Downregulated
1	GO:0006412	Translation	683	51	31.83	3.5E–04
2	GO:0009765	Photosynthesis, light harvesting	79	29	3.68	3.4E–17
3	GO:0044419	Interspecies interaction between organisms	535	28	24.93	1.4E–04
4	GO:0006633	Fatty acid biosynthetic process	172	26	8.02	4.4E–07
5	GO:0002181	Cytoplasmic translation	183	22	8.53	6.5E–05
6	GO:0046034	ATP metabolic process	162	22	7.55	4.4E–03
7	GO:0018298	Protein-chromophore linkage	49	19	2.28	1.9E–13
8	GO:0006413	Translational initiation	177	15	8.25	4.2E–03
9	GO:0006084	Acetyl-CoA metabolic process	91	13	4.24	1.4E–04
10	GO:0010142	Farnesyl diphosphate biosynthetic process, mevalonate pathway	59	11	2.75	7.4E–05
11	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	65	11	3.03	1.8E–04
12	GO:0000184	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	87	11	4.05	2.2E–03
13	GO:0006352	DNA-templated transcription, initiation	117	9	5.45	3.2E–03
14	GO:0034975	Protein folding in endoplasmic reticulum	31	7	1.44	4.5E–04
15	GO:0016126	Sterol biosynthetic process	34	7	1.58	2.4E–03
Upregulated
1	GO:0006633	Fatty acid biosynthetic process	172	10	2.86	1.8E–03
2	GO:0006986	Response to unfolded protein	85	7	1.42	6.3E–05
3	GO:0051085	Chaperone cofactor-dependent protein refolding	21	6	0.35	8.7E–07
4	GO:0006099	Tricarboxylic acid cycle	30	6	0.5	8.4E–06
5	GO:0008340	Determination of adult lifespan	92	6	1.53	4.3E–03
6	GO:0042026	Protein refolding	29	5	0.48	8.2E–04
7	GO:0010142	Farnesyl diphosphate biosynthetic process, mevalonate pathway	59	5	0.98	2.9E–03
8	GO:0006101	Citrate metabolic process	22	4	0.37	4.3E–04
9	GO:0098630	Aggregation of unicellular organisms	40	4	0.67	4.3E–03
10	GO:0042823	Pyridoxal phosphate biosynthetic process	10	3	0.17	5.0E–04
11	GO:0051131	Chaperone-mediated protein complex assembly	17	3	0.28	2.6E–03
12	GO:0000722	Telomere maintenance via recombination	19	3	0.32	3.6E–03
13	GO:0009647	Skotomorphogenesis	4	2	0.07	1.6E–03
14	GO:0034461	Uropod retraction	5	2	0.08	2.7E–03
15	GO:0097552	Mitochondrial double-strand break repair via homologous recombination	6	2	0.1	4.0E–03

^aThe “Annotated” column indicates the number of E. huxleyi CCMP3266 genes that were specified with the respective GO iD (see Data Set S2, column 21). The “Significant” column indicates the number of genes that were down- or upregulated. The “Expected” column indicates the theoretical number of down- and upregulated genes in the absence of an enrichment.