FIGURE 2.

Molecular mechanism hypothesis of rs8193069 on SCC in milk or its contribution to mastitis resistance based on results in this study. The major allele C of rs8193069 may reduce the binding ability between TLR4 protein and its adaptors. This leads to the reduced activity of NF‐κB, decreased cytokines expression and lymphocyte/basophils proliferation, resulting in reduced SCC in milk. The pathway has been described in detail in the text. IFN‐α, Interferon‐α; IFN‐β, Interferon‐β; IL‐6, interleukin‐6; IL‐8, interleukin‐8