Table 2.

Genomic testing results.

Gene	Mutation	Type	Allele frequency (%)
TP53	ENST00000269305.8:c.490A>G:exon5:p.K164E	Somatic	98
RB1	ENST00000267163.5:c.1442_1470del:exon16:p.I481fs	Somatic	98
CTNNB1	ENST00000349496.11:c.133_135del:exon3:p.S45del	Somatic	97
ATRX	ENST00000373344.10:c.1834A>T:exon9:p.K612*	Somatic	97
Other key genomic features
Low mutation burden (2.38 mutations per megabase)
High number of chromosomal breaks
Whole-genome doubling

* indicates the amino acid change leads to a stop codon.