Table 1:
Sample Characteristics
| [11C]-DASB (N=19) | [11C]-CUMI-101 (N=13) | |||||
|---|---|---|---|---|---|---|
| BPD Pre-Lithium | BPD Post-Lithium | p-value | BPD Pre-Lithium | BPD Post-Lithium | p-value | |
| Age (years) | 34.0 ± 12.3 | -- | -- | 30.5 ± 10.5 | -- | -- |
| Sex (% female) | 47.4% | -- | -- | 46.2% | -- | -- |
| HDRS-24 | 27.3 ± 4.9 | 15.5 ± 8.7 | <0.001 | 26.8 ± 4.4 | 15.9 ± 9.2 | 0.001 |
| HDRS-17 Baseline (Inclusion Criteria) |
21.1 ± 4.1 | -- | -- | 21.9 ± 3.8 | -- | -- |
| % Remitted* | -- | 26.3% | -- | -- | 23.1% | -- |
| Free Fraction (fp) | 0.1 ± 0.03 | 0.1 ± 0.03 | 0.35 | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.27 |
| Reference Region Binding** | -- | -- | -- | 6.2 ± 1.4 | 6.5 ± 1.7 | 0.61 |
Abbreviations: HDRS – Hamilton Depression Rating Scale, BPD = bipolar depression
*
remission defined as <10 on HDRS-24 post-treatment and >= 50% reduction in HDRS-24 from pre to post-treatment
**
Region: cerebellar grey matter VT (volume of distribution)