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. 2022 Jan 8;50(2):1187–1197. doi: 10.1093/nar/gkab1295

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Comparison of prime editing and base editing outcomes at the same target sites. (A, B) CBE- and PE-generated frequencies of C•G-to-T•A edits at target nucleotides, highlighted in red, in the endogenous HEK3 and FANCF sites. Base positions are numbered relative to the PAM of the CBE sgRNA. The PAM nucleotides are numbered 21–23. (C, D) ABE- and PE-generated frequencies of A•T-to-G•C edits at endogenous HEK3 and FANCF sites. **P < 0.01, ***P < 0.001, ****P < 0.0001. for (A)–(D). (E, F) Indel frequencies from the experiments in (A) and (B). (G, H) Indel frequencies from the experiments in (C) and (D). Mean ± s.d. of n = 3 independent biological replicates.