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PE does not lead to genome-wide off-target effects. (A) Schematic diagram of the experimental design for clonal expansion and whole genome sequencing analysis of H9-iPE2 cells with or without dox-induced PE2 expression for 3 weeks. (B, C) Numbers of mutations in uninduced and induced H9-iPE2 clones. The numbers represent all sequence variations, including indels and single nucleotide variations. (D) Venn diagrams showing the ratios of common SNVs in H9-iPE2 clones.
