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. 2021 Dec 30;50(2):899–914. doi: 10.1093/nar/gkab1253

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Model for DSB competition arising from the competitive loading of LinE complexes onto DSB hotspots. A loader, such as cohesin or condensin, moves along paired sister chromatids (thin black arrows) and loads LinE complexes (blue circles and ovals) onto a limited number of potential DSB hotspot sites. This prevents other sites in this traversed interval from being bound by LinEs and therefore limits DSBs to only the LinE-loaded sites (DSB competition). The ade6-3101 hotspot with a lacO array allows independent loading of Mug20-LacI and thus lacks DSB competition. The loader (cohesin or condensin) groups the LinE-hotspot complexes, including the Mug20-LacI-bound site, into a cluster, in which a DSB is formed. This DSB activates Tel1 protein kinase to prevent further DSB formation in that cluster (DSB interference).