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Inhibition curves of SAH (a natural competitive inhibitor of methyltransferases) to (A) DNMT1, (C)METTL3/14, and IOX1 (spectrum competitive inhibitor of 2-OG dependent dioxygenases) to (B) TET2 and (D)ALKBH5. Reactions were performed at different concentrations of SAM or 2-OG, in triplicate. Error bars are displayed as mean ± SD (n = 3).
