Figure 6.

Validation of CCPE prediction accuracy using scRNA-seq datasets from cells treated with cell cycle disruptors. (A) UMAP plots for 24 cancer cell lines treated with DMSO and nutlin, separately. Cells were colored by CCPE-inferred cell cycle stages and cells in red circle are TP53 WT cells. (B) The number of cells in CCPE-inferred cell cycle stages as a proportion of the total number of cells in DMSO- and nutlin-treated groups. (C) Top ten biological processes of DEGs identified from CCPE-inferred cell cycle stages.