FIG 2.

Enrichment of AA changes (difference between observed frequency and a random sample) in pBC and mBC and in mBC with pBC as a random sample for SBS2 and SBS13 (*P ≤ .05, **P ≤ .01, and ***P ≤ .001). Only AA changes with a frequency ≥ 1% in a random sample are shown. AA, amino acid; C, cysteine; E, glutamate; F, phenylalanine; H, histidine; I, isoleucine; K, lysine; L, leucine; mBC, metastatic breast cancer; mBC, metastatic breast cancer; N, asparagine; pBC, primary breast cancer; Q, glutamine; R, arginine; S, serine; SBS, single base-pair substitution; T, threonine; V, valine; X, STOP (stop codon); Y, tyrosine. APOBEC drives early, metastatic, and endocrine-resistant disease in ER+/HER2– breast cancer