Figure 2.

The switch of fluorophore does not affect the enhanced extravasation of ICLs over FPLs. (A) EPC/DSPE-PEG2000/DiD/Cy3-DSPE liposomes were used (Table 1). (B) Both dyes showed colocalization in liposomes. Note that the size estimate by fluorescence microscopy is not accurate, and readers are referred to Table 1 for accurate size and PDI measurements. (C) Confocal images of tumor slices and (D) image area quantification show predominant spreading of DiD in tumors (n = 60 images from 3 mice, paired t test).