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. 2022 Jan 25;11:e73325. doi: 10.7554/eLife.73325

Figure 2. Fibrotic remodeling.

Figure 2.

(A,B) Examples of hypertrophic cardiomyopathy (HCM) personalized left ventricular (LV) geometrical models with fibrotic remodeling (right ventricle [RV] shown in transparent gray) reconstructed using late gadolinium enhancement (LGE)-cardiac magnetic resonance (CMR) images with personalized T1-informed fibrosis segmentation thresholds (left) and using LGE-CMR images with one-size-fits-all fibrosis segmentation thresholds of 3 and 5 standard deviation [SD] (right). There is significantly more diffuse fibrosis in the T1-adjusted models. (A) Heart model from an HCM patient without clinical ventricular arrhythmia (VA). (B) Heart model from an HCM patient with clinical VA. (C) Boxplot of the amount of diffuse fibrosis in LGE-T1 and LGE-only HCM geometrical models without clinical VA (LGE-T1: N = 13, interquartile range [IQR] = 12.54; LGE only: N = 13, IQR = 2.41; *p < 0.0001) and with clinical VA (LGE-T1: N = 13, IQR = 14.44; LGE only: N = 13, IQR = 2.46; **p < 0.0001). The '+' denotes an outlier.

Figure 2—source data 1. Spreadsheet including source data underlying Figure 2.