Figure 2 .

Overview of chromosome organization changes in RS and OIS. Long-range interactions increase while short-range interactions decrease [83]. There is evidence of compartment switching with more B to A than A to B compartment switches [82]. TADs are largely unchanged in both types of senescence, although a less commonly used method identified changes such as fusing and shifting TADs in RS [43, 79, 86]. In RS, there is evidence of de novo long-range CTCF loops formed across sites occupied by HMGB2 in proliferating but not senescent cells [43]. In OIS, de novo loops connecting enhancers and promoters were observed [86].