Table 2.

Age-related changes to phagocytosis of different populations of macrophages

Population	Species	Strain	Ages	Sex	Phagocytosis cargo	Age-related change	Reference
Alveolar macrophages	R. norvegicus	F-344xBN	6 m versus 12 m versus 18 m	NA	Opsonized K. pneumoniae 43,816	increase	[138]
	M. musculus	C57BL/6	2-4 m versus 16 m versus 22–24 m versus 33 m	NA	Alexa Fluor 488 beads	decrease	[56]
Bone marrow-derived macrophages (in vitro differentiation)	M. musculus	C57BL/6	2–4 m versus 18–22 m	F	S. pneumoniae	decrease	[18]
	M. musculus	C57BL/6	2–3 m versus 15–20 m	M	Fluorescent particles	no difference	[139]
Bone marrow macrophages (in vivo)	M. musculus	C57BL/6 J	2–4 m versus 20–30 m	M	Senescent neutrophils	decrease	[51]
Kupffer Cells	R. norvegicus	F344	~1 m versus 12 m versus 24–25 m	M	Polystyrene/sucrose microsphere	increase	[140]
Microglia	M. musculus	C57Bl/6 J	2–3 m versus 20–22 m	M	Fluoresbrite Yellow Green Carboxylate microsphere (1 μm)	decrease	[141]
Peritoneal Macrophages	M. musculus	BALB/c	3 m versus 15 m	B	Latex beads (1.09 μm)	decrease	[142]
	M. musculus	BALB/c	3–4 m versus 20–23 m	B	Latex beads (1.09 μm)	decrease	[143]
	M. musculus	BALB/c	3 m versus 15 m	M	Opsonized Candida albicans Latex beads Latex beads (1.09 μm)	No change	[144]
	M. musculus	C57BL/6	2–4 m versus 18–22 m	F	S. pneumoniae	decrease	[18]
	M. musculus	C57BL/6	2–3 m versus 15–20 m	M	Fluorescent particles	decrease	[139]
	M. musculus	BALB/c	2 m versus 20 m	M	Apoptotic neutrophils	decrease	[50]
	M. musculus	CF-1	3 m versus 22 m	M	Carbon uptake	decrease	[145]
Thiogallate-induced peritoneal exudate macrophages	M. musculus	B6C3-F1 B6.Gld	2 m versus 24 m	M	Apoptotic TAMRA/SE-labeled apoptotic Jurkat T cells	decrease	[146]

F: Female; M: Male; B: both sexes; NA: sex not specified in the article; m: months.