Fig. 3.
Predictions of selection coefficients on simulated regions using SIA and CLUES based on true genealogies. (A) The distribution of inferred selection coefficients for each method under each model condition are reported using a box plot. The box plot for each method reports these five statistics (from bottom to top): minimum, first quartile, median, third quartile, and maximum. The y-axis shows the inferred selection coefficient, whereas the x-axis shows the true selection coefficient. The dashed-black line indicates the true selection coefficient for each model condition. The simulations are based on the CEU demographic model and true genealogies were used as input to both methods. Each model condition (i.e., box plot) represents a set of 400 independent simulations. The mean ranks and variances of the distributions of inferred s were compared using the Wilcoxon signed-rank test (pW) and the Brown–Forsythe test (pBF), respectively. (B) The root mean square error (RMSE) for each method under each model condition evaluated on 400 independent simulations.