Table 5.
miRNA-mediated regulation of histone lysine methyltransferases.
| Site of methyl group addition | Target gene | miRNAs | Cancer tissue or cancer cell line | Reference |
|---|---|---|---|---|
| H3K9 | SUV39H1 (KMT1A) | miR-125a-5p | Gastric cancer | [83] |
| SUV39H1 (KMT1A) | miR-125b | Hepatocellular carcinoma cells | [84] | |
| SUV39H1 (KMT1A) | miR-122 | Hepatocellular carcinoma cells | [85] | |
| SUV39H2 (KMT1B) | miR-675 | Liver stem cells | [86] | |
| G9a (KMT1C) | miR-212 | Lung cancer (NSCLC) | [87] | |
| SETDB1 (KMT1E) | miR-381-3p | Breast cancer | [88] | |
| H3K4 (MLL1) | Mll1 (KMT2A) | miR-22-3p | Prostatic cancer | [89] |
| H3K36 | ASH1L (KMT2H) | miR-142 | Leukemia | [90] |
| ASH1L (KMT2H) | miR-142 | Thyroid tumors | [91] | |
| KMT3B (NSD1) | miR-181a | Endometrial cancer | [92] | |
| H4K5 | SMYD3 (KMT3E) | miR-124 | Cholangiocarcinoma | [93] |
| SMYD3 (KMT3E) | miR-346 | Hepatocellular carcinoma | [94] | |
| H3K79 | DOT1L (KMT4) | miR-133b | Colorectal cancer | [95] |
| H4K20 | SET8 (KMT5A) | miR-502 | Breast cancer | [96] |
| SET8 (KMT5A) | miR-502 | Ovarian cancer | [97] | |
| SET8 (KMT5A) | miR-502 | Non-small-cell lung cancer | [98, 99] | |
| SET8 (KMT5A) | miR-502 | Colorectal cancer | [100] | |
| SET8 (KMT5A) | miR-502 | Non-Hodgkin's lymphoma | [101] | |
| SET8 (KMT5A) | miR-502 | Esophageal squamous cell carcinoma | [102] | |
| SET8 (KMT5A) | miR-502 | Clear cell renal cell carcinoma | [103] | |
| SET8 (KMT5A) | miR-502 | Hepatocellular carcinoma | [104] | |
| SET8 (KMT5A) | miR-7 | Breast cancer | [105] | |
| H3K27 | KMT6B (EZH1) | miR-17-5p | NSCLC | [106] |
| KMT6B (EZH1) | miR-765 | Breast cancer | [107] | |
| KMT6B (EZH1) | miR-93 | Breast cancer stem cells | [108] | |
| KMT6B (EZH1) | miR-574-5p | Prostate cancer stem cells | [109] | |
| KMT6 (EZH2) | miR-101 | NSCLC | [110] | |
| KMT6 (EZH2) | miR-101 | Prostate cancer | [111] | |
| KMT6 (EZH2) | miR-101 | renal cancer | [112] | |
| KMT6 (EZH2) | miR-101 | Endometrial cancer | [113] | |
| KMT6 (EZH2) | miR-26a | Lung cancer | [114] | |
| KMT6 (EZH2) | miR-26a | Burkitt lymphoma | [115] | |
| KMT6 (EZH2) | miR-26a | Rhabdomyosarcoma | [116] | |
| KMT6 (EZH2) | miR-26a | Prostate cancer | [117] | |
| KMT6 (EZH2) | miR-26a | Nasopharyngeal carcinoma | [118] | |
| KMT6 (EZH2) | miR-137 | Liver cancer | [119] | |
| KMT6 (EZH2) | miR-124 | Hepatocellular cell carcinoma | [120] | |
| KMT6 (EZH2) | miR-138 | Squamous cell carcinoma cell lines | [121] | |
| KMT6 (EZH2) and HDAC3 | miR-31 | Esophageal cancer | [125] | |
| KMT6 (EZH2) | miR-98 | Ovarian cancer stem cells | [126] |