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. 2022 Jan 12;9:811417. doi: 10.3389/fbioe.2021.811417

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Copyright © 2022 Murray, Gumusoglu, Santillan and Santillan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dendritic cells are modulated by T cells and NK cells in preeclampsia. Oxidative and vascular stress contribute to preeclamptic conditions. In preeclampsia, there is an increase of cytolytic, type 1 NK cells and precocious maturation of DCs, as well as increased production of pro-inflammatory cytokines. There is a simultaneous decrease in non-cytolytic, type 2 NK cells and anti-inflammatory cytokines. All three cell types interact to aggravate the elevated pro-inflammatory status that contributes to and occurs in preeclampsia. NK, natural killer; DC, dendritic cells. Created with https://biorender.com.