Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 12;9:811417. doi: 10.3389/fbioe.2021.811417

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Murray, Gumusoglu, Santillan and Santillan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Cytolytic NK cells may be targeted in preeclampsia. Induction of non-cytolytic NK cells and inhibition of cytolytic NK cells is one potential avenue for the treatment and prevention of preeclampsia. Anti-TLR5, anti-IL-6, and anti-CD28 inhibit IL-6’s activation of pro-apoptotic cytolytic type 1 NK cells. Anti-CD28 also directly inhibits type 1 NK cells, and promotes non-cytolytic, type 2 NK cells and the anti-apoptotic cytokines IL-10 and IFN-γ. 17-OHPC works similarly to promote type 2 NK cells. Together, these reduce the cytolytic NK cell response, which can lead to improper placentation and subsequent preeclampsia. 17-OHPC, 17-hydroxyprogesterone caproate; anti, antibody; IFN-γ, interferon gamma; NK2, non-cytolytic, type 2 Natural Killer cells; IL, interleukin; NK1, cytolytic, type 1 Natural Killer cells; TNF-α, tumor necrosis factor alpha; TLR5, toll like receptor 5. Created with https://biorender.com.