Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 12;12:788976. doi: 10.3389/fimmu.2021.788976

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Poh, Loh, Friedland and Ong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Neutrophil extracellular traps (NETs) promote thrombosis in brain microvessels. (A) Platelets interact with C3b and histones on NETs to stimulate the secretion of polyP which activates the extrinsic coagulation pathway. (B) Platelet-derived HMGB1 induces NETosis. (C) Multiple components of NETs induce coagulation either directly or by inhibiting the extrinsic coagulation pathway inhibitor. (D) NE is able to generate thrombin-derived immune modulatory peptides. (E) Fibrin fibres strengthened by NETs immobilize M. tb and are less prone to degradation by plasmin. Illustration created with Biorender.com.