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. 2022 Jan 12;15:757628. doi: 10.3389/fnins.2021.757628

FIGURE 4.

FIGURE 4

Electroacupuncture relieves hyperalgesia and anxiety-like behaviors in SNI mice models. (A) Schematic diagram of the experimental process. (B) Schematic diagram of the EA treatment. (C) Time course of the SNI-induced changes in the PWTs. (D) Time spent in the open arms by the mice in the EPM test. (E) The entries in the open arms show no significant difference among the three groups. (F) Representative movement trajectory diagram and activity heatmap of the mice in the EPM test for each group. (G) Time spent by the mice in the center of the field in the OFT. (H) Center distance in the OFT. (I) Total distance traveled in the OFT. (J) Representative movement trajectory diagram and activity heatmap of the mice in the OFT for each group. Data are presented as means ± standard errors of the means. *P < 0.05 vs. the sham group; #P < 0.05 vs. the SNI group; &P < 0.05 vs. the SNI + sham EA group; NS, not significant. n = 10–11 mice per group in (C–E); n = 9–10 mice per group in (G–I). EA, electroacupuncture.