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. 2022 Jan 25;12:1317. doi: 10.1038/s41598-022-05243-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Prognostic associations in TCGA and PRECOG. (A) Correlation matrix of TP53 signatures using Spearman correlation coefficients (SCC). (B) KM plots for UCEC in TCGA based on TP53 mutation status (left) or p53 deficiency scores (PDS) (right). (C) KM plots for LUAD in TCGA based on TP53 mutation status (left) or PDS (right). LR p-value calculated between groups using Log-rang tests, HR hazard ratio. (D) Meta-p-values for association between PDSs and prognosis in PRECOG. Bars indicate − log10(meta p-values). Negative values indicate a hazardous role for PDSs, while positive values represent protective associations. LGG (brain lower grade glioma), GBM (glioblastoma multiforme), SARC (sarcoma), KICH (kidney chromophobe), READ (rectum adenocarcinoma), COAD (colon adenocarcinoma), ESCA (esophageal carcinoma), LUSC (lung squamous cell carcinoma), SKCM (skin cutaneous melanoma), PRAD (prostate adenocarcinoma), STAD (stomach adenocarcinoma), LIHC (liver hepatocellular carcinoma), OV (ovarian serous cystadenocarcinoma), UCEC (uterine corpus endometrial carcinoma), BRCA (breast invasive carcinoma), LUAD (lung adenocarcinoma), BLCA (bladder urothelial carcinoma), UCS (uterine carcinosarcoma), HNSC (head and neck squamous cell carcinoma), PAAD (pancreatic adenocarcinoma).