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. 2022 Jan 25;12:1299. doi: 10.1038/s41598-022-05424-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phylogenic tree analysis, temporal trends in Japan registered by GISAID database. (a) Most of the Japanese strains were derived from National Institute of Infectious Diseases (NIID) submitted on 10th January 2021 in GISAID excluding airport quarantine, but were not specified by towns/cities or precise obtaining dates (obtaining month only). Therefore, we designated all the NIID data for the first day of the month (i.e., 2020/4 → 2020/4/1). A magnified view of the dotted square is shown in Supplementary Fig. 1. (b) Temporal trends of the number of patients of Clade 20B-T (B.1.1.284) and Clade 20B-nonT in Japan. (c) The cumulative frequency of Clade 20B-T (B.1.1.284) in Japan. COVID-19, coronavirus disease 2019; NSP, Non-structural polyprotein; PL^pro, papain-like proteinase; 3CL^pro, 3 chymotrypsin-like protease; RdRp, RNA dependent RNA polymerase; ORF, open reading frame.