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. 2022 Jan 25;12:1357. doi: 10.1038/s41598-022-04906-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tmprss2 mRNA expression is upregulated in the lungs of ozone -exposed mice. FPKM values obtained from RNAseq data set obtained from airways (A), parenchyma (B), and alveolar macrophages (C) were used to quantify relative expression levels of Tmprss2 mRNA in air- versus ozone-exposed mice (n = 8). The data are expressed as mean (± SEM). Student’s t-Test; *P < 0.05, **P < 0.01, ****P < 0.0001. (D) RNAscope-based in situ hybridization for Tmprss2 transcripts (green dots representing punctate staining for Tmprss2 mRNA in airway epithelial cells (Top) and alveolar epithelial cells (bottom) in air- (left) and ozone-exposed (right) mice. All images were captured at the same magnification. FPKM values obtained from RNAseq data set obtained from airways (E), parenchyma (F), and alveolar macrophages (G) were used to quantify relative expression levels of Ace2 mRNA in air- versus ozone-exposed mice (n = 8). The data are expressed as means (± SEM). Student’s t-Test ** P < 0.01. (H) Duplex RNAscope-based in situ hybridization for Tmprss2 (green puncta, green arrow) and Ace2 (red puncta, red arrow) in the airways of air- (left) and ozone-exposed (right) mice. All images were captured at the same magnification.