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. 2022 Jan 25;12:1294. doi: 10.1038/s41598-022-05400-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Longitudinal data in the AI group are shown by box plots. (A) White blood cell counts, (B) absolute eosinophil counts, (C) relative eosinophil counts, (D) C-reactive protein levels, (E) serum urea nitrogen levels, (F) serum creatinine levels, (G), serum sodium levels, (H) serum potassium levels, and (I) plasma glucose levels. ‘Baseline’ represents data before the first administration of ICIs. ‘Pre-onset’ represents data checked-up just before the patients experienced AI symptoms. ‘irAE’ represents data at the diagnosis of ICI-induced secondary AI. Statistical analyses were performed by Friedman’s test corrected by Bonferroni’s method. Significant differences of p < 0.05 were indicated.