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. 2022 Jan 25;13:493. doi: 10.1038/s41467-022-28040-1

Fig. 6. Neuronal response to ultrasound is amplified by calcium-gated and voltage-gated ion channels.

Fig. 6

a Illustration of the molecular pathway activated by ultrasound. b Calcium responses from wild type neurons and modified neurons with CRISPR/Cas9 for TRPM4 knock down (n = 7 independent experiments for control, and 12 independent experiments for TRPM4, Unpaired T-test, two-tailed, p = 0.0024). c Calcium responses before and after treatment with the t-type calcium channel blocker TTA-P2 (3 μM, n = 5 independent experiments, paired T-test, two-tailed, p = 0.0331). Mean trace is solid and SEM is shaded. Bar graph values represent mean ± SEM.