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. 2022 Jan 25;12:1372. doi: 10.1038/s41598-022-05404-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Overall workflow for the identification and validation of emergent phenotypes associated to the combined exposure to surrogates of CV risk factors such as hypoxia (CoCl₂), Oxidized lipids (OxPAPC), inflammation (IL-1β) and OSS on human coronary artery endothelial cells (HCAEC). 1 Experimental design for in vitro exposure of HCAEC to individual or combined stimuli. 2 Global gene expression and gene regulatory network analyses. 3 Orthogonal validation using scRNA-seq data from human coronary atherosclerotics plaques (dataset GSE131778). The cartoons were created using the Mind the Graph platform (www.mindthegraph.com) and data presented in the manuscript to illustrate the overall workflow.