Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 25;12:1372. doi: 10.1038/s41598-022-05404-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Gene expression profile revealed the hierarchical contribution of the CVD risk factors CoCl₂, OxPAPC, IL-1β and OSS and key TFs relevant to endothelial function. (a) Principal Component Analysis (PCA) of gene expression profile from each sample showed that the PC1 explained 20.4% of the variation while PC2 16.2%. (b) Hierarchical clustering heatmap using Euclidean distance as a measured parameter revealed details of hierarchical contribution by each condition according to their distance to the LSS. (c) Volcano plot showed the differentially expressed genes (DEGs) when comparing the clustered risk factors vs. LSS. The DEGs were considered as adjusted p-value < 0.05 and |Log2foldchange|> 1.3. (d) TF identified among the DEGs and their respective log2 foldchange. Genes in blue are downregulated and in red are upregulated.