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. 2022 Jan 25;12:1340. doi: 10.1038/s41598-022-05060-x

Figure 6.

Figure 6

Asprosin levels in serum correlate with the cartilage marker COMP upon hip replacement surgery. (A) (left) Absolute serum asprosin (ng/ml) for each patient before and until one year after total hip replacement (THR). (right) Relative asprosin concentration after THR (t1, t2, and t3) normalized to serum asprosin at baseline (t0, before THR). (B) (left) Absolute serum COMP (ng/ml) for each patient before and until one year after THR. (right) Relative serum COMP (%) after THR (t1, t2, and t3) normalized to serum COMP at baseline (t0, before THR). n = 14 patients; time points: t0: within 1 week before THR, t1: 7 days postoperative, t2: 3 months postoperative, t3: about 1 year postoperative. ***P = 0.0003, **P = 0.0056. Serum (25 µl) fourfold diluted in PBS (75 µl) for asprosin concentration analysis, and 2 µl serum 50-fold diluted in 98 µl PBS for COMP concentration analysis. Data were analyzed using Graphpad Prism version 8.0.2.