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. 2022 Jan 25;12:1313. doi: 10.1038/s41598-022-04785-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Western blotting analysis of inflammatory markers. Effect of RA and CP on the expression of COX-2 and NFκB-p65 in mouse kidney tissue as studied by western blot analysis is shown in (a) by immunoblots of inflammatory markers COX-2 and NFκB-p65. The administration of CP caused an increase in the expression of COX-2 and NFκB-p65 proteins when compared with control group of animals. While the treatment of RA along with the administration of CP decreases the expression of COX-2 and NFκB-p65 proteins when compared with CP alone treated group of mice. In this figure histograms (b) and (c) represent significant differences between CP and CP + RA100 treated group of animals. The treatment of CP caused a significant increase in the expression of COX2 (***p < 0.001) and NFκB-p65 (***p < 0.001) proteins when compared with control group of animals. However, the treatment of RA along with CP caused a significant restoration in the expression of COX-2 (^##p < 0.01) and NFκB-p65 (^#p < 0.05) proteins when compared with CP alone treated group of mice. No significant differences were noticed in RA alone treated group of animals when compared with control group of animals. Data are expressed as means ± SEM (n = 6).